Department of Chemistry and Biochemistry, University of Bern, Switzerland


Suter C, Colakovic M, Bieri J, Gultom M, Dijkman R, Ros C. 2023. Globoside and the mucosal pH mediate parvovirus B19 entry through the epithelial barrier. PLoS Pathog. 19, e1011402.

Bircher C, Bieri J, Assaraf R, Leisi R, Ros C. 2022. A Conserved Receptor-Binding Domain in the VP1u of Primate Erythroparvoviruses Determines the Marked Tropism for Erythroid Cells. Viruses 14:420.

Leisi R, Rostami I, Laughhunn A, Bieri J, Roth N, Widmer E, Ros C. 2022. Visualizing protein fouling and its impact on parvovirus retention within distinct filter membrane morphologies. J Memb Sci. 659, 120791.

Bieri J, Leisi R, Bircher C, Ros C. 2021. Human parvovirus B19 interacts with globoside under acidic conditions as an essential step in endocytic trafficking. PLoS Pathog. 17, e1009434.

Meier A,Tobler K, Leisi R, Lkharrazi A, Ros C, Fraefel C. 2021. Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome. PLoS Pathog. 17, e1009638.

Leisi R, Widmer E, Gooch B, Roth NJ, Ros C. 2021. Mechanistic insights into flow-dependent virus retention in different nanofilter membranes. J Membr Sci. 636, 119548.

Leisi R, Wolfisberg R, Nowak T, Caliaro O, Hemmerle A, Roth NJ, Ros C. 2021. Impact of the isoelectric point of model parvoviruses on viral retention in anion-exchange chromatography. Biotechnol & Bioeng. 118, 116-129.

Ros C, Bieri J, Leisi R. 2020. The VP1u of Human Parvovirus B19: A Multifunctional Capsid Protein with Biotechnological Applications. Viruses 12, 1463.

Leisi R, Bieri J, Roth NJ, Ros C. 2020. Determination of Parvovirus Retention Profiles in Virus Filter Membranes Using Laser Scanning Microscopy. J Membr Sci. 603, 118012.

Bieri J, Ros C. 2019. Globoside is dispensable for parvovirus B19 entry but essential at a postentry step for productive infection. J Virol. 93, e00972-19.

Caliaro O, Marti A, Ruprecht N, Leisi R, Subramanian S, Hafenstein S, Ros C. 2019. Parvovirus B19 uncoating occurs in the cytoplasm without capsid disassembly and it is facilitated by depletion of capsid-associated divalent cations. Viruses 11, 430.

Bochud M, Schäfer W, Roth NJ, Ros C. 2019. Characterization of a quasi-enveloped, fast replicating hepevirus from fish and its use as hepatitis E virus surrogate. J Virol Meth. 263, 111-119.

Ros C, Bayat N, Wolfisberg R, Almendral JM. 2017. Protoparvovirus Cell Entry. Viruses 9, 11.

von Nordheim M, Boinay M, Leisi R, Kempf C, Ros C. 2016. Cutthroat trout virus – a virus model to support hepatitis E research. Viruses 8, 10.

Leisi R, von Nordheim, Ros C, Kempf C. 2016. The VP1u Receptor Restricts Parvovirus B19 Uptake to Permissive Erythroid Cells. Viruses 8, 10.

Wolfisberg R, Kempf C, Ros C. 2016. Late maturation steps preceding selective nuclear export and egress of progeny parvovirus. J Virol. 90, 5462-5474.

Leisi R, Di Tommaso C, von Nordheim M, Kempf C, Ros C. 2016. Characterization of the Receptor-Binding Domain of Parvovirus B19 that Mediates Viral Uptake into Permissive Cells. Viruses 8, 3.

Leisi R, von Nordheim M, Kempf C, Ros C. 2015. Specific Targeting of Proerythroblasts and Erythroleukemic Cells by the VP1u Region of Parvovirus B19. Bioconjug Chem. 26, 1923-1930.

Ros C. 2014. Going Viral. International Innovation. Research Media Ltd. 131, 63-65.

Wolfisberg R, Ruprecht N, Kempf C, Ros C. 2013. Impaired genome encapsidation restricts the in vitro propagation of human parvovirus B19. J Virol Meth. 193, 215-225.

Leisi R, Ruprecht N, Kempf C, Ros C. 2013. Parvovirus B19 uptake is a highly selective process controlled by VP1u, a novel determinant of viral tropism. J Virol. 87, 13161-13177.

Quattrocchi S, Ruprecht N, Bönsch C, Bieli S, Zürcher C, Boller K, Kempf C, Ros C. 2012. Characterization of the early steps of human parvovirus B19 infection. J Virol. 86, 9274-9284.

Ros C. 2010. Schädliche Medizin. Neues aus de Wissenschaft. NZZ am Sonntag. 9 May 2010, 57.

Bönsch C, Zuercher C, Lieby P, Kempf C, Ros C. 2010. The globoside receptor triggers structural changes in the B19 virus capsid that facilitate virus internalization. J Virol. 84,11737-11746.

Bönsch C, Kempf C, Mueller I, Manning L, Laman M, Davis T, Ros C. 2010. Chloroquine and amodiaquine promote human parvovirus B19 infection. A risk factor for severe anemia in children from malaria endemic regions. PLoS Negl Trop Dis. 27, 4(4):e669.

Bönsch C, Kempf C, Ros C. 2008. Interaction of parvovirus B19 with human erythrocytes alters virus structure and cell membrane integrity. J Virol. 82, 11784-11791.

Mani B, Gerber M, Lieby P, Boschetti N. Kempf C, Ros C. 2007. Molecular mechanisms underlying human parvovirus B19 inactivation and comparison to other parvoviruses. Transfusion 47, 1765-1774.

Mani B, Baltzer C, Valle N, Almendral JM, Kempf C, Ros C. 2006. Low pH-dependent endosomal processing of the incoming parvovirus MVM virion leads to N-VP1 externalization, N-VP2 cleavage and uncoating of the full-length genome. J Virol. 80, 1015-1024.

Ros C, Baltzer C, Mani B, Kempf C. 2006. Parvovirus uncoating in vitro reveals a mechanism of DNA release without capsid disassembly and striking differences in encapsidated DNA stability. Virology 345, 137-147.

Ros C, Gerber M, Kempf C. 2006. Conformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences playing a role in virus neutralization and infectivity. J Virol. 80, 12017-12024.

Ros C, Kempf C. 2004. The ubiquitin-proteasome machinery is essential for nuclear translocation of incoming minute virus of mice. Virology 324, 350-360.

Ros C, Burckhardt C, Kempf C. 2002. Cytoplasmic trafficking of MVM. Low pH requirement, routing to late endosomes and proteasome interaction. J Virol. 76, 12634-12645.


Previous publications


Ros  C,  Belák  S.  2002.  Characterization  of  the  glycoprotein  B gene  from  ruminant alphaherpesviruses. Virus Genes 24, 99-105.

Farsang  A,  Ros  C,  Renström  L,  Baule  C,  Soós  T,  Belák  S.  2002.  Molecular epizootiology of infectious bronchitis virus in Sweden indicating the involvement of a vaccine strain. Avian pathology 31, 229-236.

Nordengrahn A, Merza M, Ros C, Lindholm A, Pálfi V, Hannant D, Belák S. 2002. Prevalence of equine herpesvirus types 2 and 5 in horse populations by using type- specific PCR assays. Vet Res. 33, 251-259.

Schynts  F,  Lemaire  M,  Ros  C,  Belak  S,  Thiry  E.  2001.  Establishment  of  latency associated with glycoprotein E (gE) seroconversion after bovine herpesvirus 1 infection in calves with high levels of passive antibodies lacking gE antibodies. Vet Microbiol. 82, 211-222.

Lemaire M, Schynts F, Meyer G, Georgin J, Baranowski E, Gabriel A, Ros C, Belak S, Thiry E. 2001. Latency and reactivation of a glycoprotein E negative bovine herpesvirus type 1 vaccine: influence of virus load and effect of specific maternal antibodies. Vaccine 19, 4795-4804.

Six A, Banks M, Engels M, Ros C, Ackermann M. 2001. Latency and reactivation of bovine herpesvirus 1 (BHV-1) in goats and of caprine herpesvirus 1 (CapHV-1) in calves. Arch Virol. 146, 1325-1335.

Meyer G, Lemaire M, Ros C, Belak K, Gabriel A, Cassart D, Coignoul F, Belak S, Thiry E. 2001. Comparative pathogenesis of acute and latent infections of calves with bovine herpesvirus types 1 and 5. Arch Virol. 146, 633-652.

Egyed L, Ros C, Belak S. 2000. Genomic and pathogenic studies on a glycoprotein E variant field isolate of bovine herpesvirus 1. Vet Res Commun. 24, 423-431.

Ros C, Riquelme ME, Forslund KO, Belak S. 1999. Improved detection of five closely related   ruminant   alphaherpesviruses   by   specific   amplification   of   viral   genomic sequences. J Virol Methods 83, 55-65.

Belak  S,  Stadejek  T,  Björklund  H,  Ros  C,  Ciabatti  IM,  Scicluna  MT,  Amaddeo  D, McCollum  WH,  Paton  DJ,  Autorino  GL,  Timoney  PJ,  Klingeborn  B.  1999.  Genetic diversity among field isolates of equine arteritis virus. In: Equine Infectious Diseases VIII (P.J. Timoney, ed.). R&W Publications, Newmarket, UK, p. 177-183.

Belak K, Kucsera L, Ros C, Kulcsar G, Makranszki L, Soos T, Belak S. 1999. Studies on the pathogenicity of bovine herpesvirus type 5 in sheep. Comp Immunol Microbiol Infect Dis. 22, 207-220.

Belak  S,  Ros  C.  1999.  Alphaherpesviruses  of  ruminants:  filogenetic  studies  and molecular diagnostics. Magyar Allatorvosok Lapja 121, 200-208.

Ros C, Belak S. 1999. Studies of genetic relationships between bovine, caprine, cervine, and rangiferine alphaherpesviruses and improved molecular methods for virus detection and identification. J Clin Microbiol. 37, 1247-1253.

Stadejek T, Bjorklund H, Ros C, Ciabatti IM, Scicluna MT, Amaddeo D, McCollum WH, Autorino GL, Timoney PJ, Paton DJ, Klingeborn B, Belak S. 1999. Genetic diversity of equine arteritis virus. J Gen Virol. 80, 691-699.

Kiss I, Ros C, Kecskemeti S, Tanyi J, Klingeborn SB, Belak S. 1999. Observations on the quasispecies composition of three animal pathogenic RNA viruses. Acta Vet Hung. 47, 471-480.

Belak S, Ros C. 1998. Use of the polymerase chain reaction in epizootiological studies of viral diseases. Towards livestock disease diagnosis and control in the 21st century. Proceedings of the IAEA/FAO symposium on diagnosis and control of livestock diseases using nuclear and related techniques. Vienna, IAEA.

Ros C, Nowotny N, Belak S. 1997. Detection and differentiation of rabbit hemorrhagic disease and European brown hare syndrome viruses by amplification of VP60 genomic sequences from fresh and fixed tissue specimens. J Clin Microbiol. 35, 2492-2495.

Ros C, Bjornerot L, Ballagi-Pordany A, Robertsson JA, Belak S. 1997. Detection of pseudorabies virus genomic sequences in apparently uninfected ‘single reactor’ pigs. Vet Microbiol. 55, 37-47.

Nowotny N,  Ros  C,  Ballagi-Pordany A,  Gavier-Widen  D,  Uhlen  M,  Belak  S.  1997. Phylogenetic analysis of rabbit haemorrhagic disease and European brown hare syndrome viruses by comparison of sequences from the capsid protein gene. Arch Virol. 142, 657-673.

Ros C, Belak K. 1996. Detection and identification of mycobacteria in formalin-fixed, paraffin-embedded tissues by nested PCR and restriction enzyme analysis. J Clin Microbiol. 34, 2351-2355.

Bolske  G,  Mattsson  JG,  Ros  C,  Bergstrom  K,  Wesonga  H,  Johansson  KE.  1996. Diagnosis of  contagious caprine pleuropneumonia  by detection  and  identification of Mycoplasma capricolum subsp. capripneumoniae by PCR and restriction enzyme analysis. J Clin Microbiol. 34, 785-791.

Chavez Gonzalez YR, Ros C, Bolske G, Mattsson JG, Fernandez Molina C, Johansson KE. 1995. In vitro amplification of the 16S rRNA genes from Mycoplasma bovis and Mycoplasma agalactiae by PCR. Vet Microbiol. 47, 183-190.

Belak S, Ballagi-Pordany A, Ros C. 1994. Aplicación de la reacción en cadena por la Polimerasa (PCR) para el diagnóstico en virología veterinaria. Investigación Agraria, Prod. Sanid. Anim. 9, 147-169.

Ros C, Mattsson JG, Bolske G, Johansson KE. 1994. Characterization of the 16S rRNA genes from Mycoplasma sp. strain F38 and development of an identification system based on PCR. J Bacteriol. 176, 2577.